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PTEN is detected as a mutational cancer driver in 2 Glioblastoma multiforme projects

Glioblastoma multiforme
Projects 2
379 Samples
Coding sequence mutations (CSMs)
in driver genes 842
in all genes 34259
Protein affecting mutations (PAMs)
in driver genes 766
in all genes 17598
PTEN
Ensembl id ENSG00000171862
Mutated samples
Coding Sequence 116 (30.6%)
Protein Affecting 115 (30.3%)
Mode of action Loss of function
Known driver Yes
Project Signals
GBM_JHU F
GBM_TCGA RF
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Glioblastoma multiforme projects in all PTEN gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Glioblastoma multiforme TCGA Yes 89 89 23.48
Glioblastoma multiforme Johns Hopkins University Yes 27 26 6.86
The mutations needle plot shows the distribution of the observed PTEN cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification