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PRPF40A has not been detected as a mutational cancer driver

PRPF40A
Ensembl id ENSG00000196504
Mutated samples
Coding Sequence 60 (0.9%)
Protein Affecting 34 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PRPF40A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 10 6 1.63
Hepatocarcinoma No 9 4 4.44
Breast carcinoma No 7 4 0.35
Lung squamous cell carcinoma No 5 4 2.30
Lung adenocarcinoma No 5 3 0.77
Bladder carcinoma No 3 2 2.04
Stomach adenocarcinoma No 4 2 1.24
Colorectal adenocarcinoma No 2 2 0.87
Glioblastoma multiforme No 2 2 0.53
Uterine corpus endometrioid carcinoma No 1 1 0.43
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Head and neck squamous cell carcinoma No 3 1 0.27
Esophageal carcinoma No 1 1 0.68
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence