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PRKD3 has not been detected as a mutational cancer driver

PRKD3
Ensembl id ENSG00000115825
Mutated samples
Coding Sequence 74 (1.1%)
Protein Affecting 51 (0.8%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PRKD3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma No 11 9 2.40
Lung adenocarcinoma No 11 7 1.79
Breast carcinoma No 8 6 0.52
Cutaneous melanoma No 10 5 1.36
Bladder carcinoma No 3 3 3.06
Serous ovarian adenocarcinoma No 4 3 0.95
Renal clear cell carcinoma No 3 2 0.48
Uterine corpus endometrioid carcinoma No 2 2 0.87
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 2 2 0.87
Glioblastoma multiforme No 2 2 0.53
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 1 1 0.51
Medulloblastoma No 1 1 0.48
Lung squamous cell carcinoma No 4 1 0.57
Thyroid carcinoma No 2 1 0.31
Multiple myeloma No 1 1 1.45
Stomach adenocarcinoma No 2 1 0.62
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence