IntOGen - PRKCB gene cancer mutations

PRKCB is detected as a mutational cancer driver

PRKCB reports

Methods
Mutation distribution

Gene details

PRKCB
Ensembl ID ENSG00000166501 Transcript ID ENST00000643927 Protein ID ENSP00000496129
Cancer types where is driver 4 Cohorts where is driver 4 Mutated samples 69 Mutations 535
Mode of action Activating
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence