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PRDM5 has not been detected as a mutational cancer driver

PRDM5
Ensembl id ENSG00000138738
Mutated samples
Coding Sequence 68 (1.0%)
Protein Affecting 47 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PRDM5 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 13 11 2.98
Head and neck squamous cell carcinoma No 7 6 1.60
Lung adenocarcinoma No 5 5 1.28
Lung squamous cell carcinoma No 7 5 2.87
Bladder carcinoma No 4 4 4.08
Breast carcinoma No 4 3 0.26
Uterine corpus endometrioid carcinoma No 3 3 1.30
Renal clear cell carcinoma No 2 2 0.48
Stomach adenocarcinoma No 4 2 1.24
Glioblastoma multiforme No 2 2 0.53
Pancreas adenocarcinoma No 1 1 0.47
Lower grade glioma No 2 1 0.59
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Hepatocarcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 6 0 0.00
Pylocytic astrocytoma No 2 0 0.00
Esophageal carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence