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PPP3CA has not been detected as a mutational cancer driver

PPP3CA
Ensembl id ENSG00000138814
Mutated samples
Coding Sequence 40 (0.6%)
Protein Affecting 28 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PPP3CA gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 11 6 1.63
Lung adenocarcinoma No 5 4 1.02
Bladder carcinoma No 5 4 4.08
Lung squamous cell carcinoma No 4 4 2.30
Breast carcinoma No 3 3 0.26
Stomach adenocarcinoma No 3 3 1.86
Prostate adenocarcinoma No 1 1 0.41
Renal clear cell carcinoma No 1 1 0.24
Non small cell lung carcinoma No 1 1 3.23
Colorectal adenocarcinoma No 1 1 0.44
Chronic lymphocytic leukemia No 4 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence