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PPARGC1A has not been detected as a mutational cancer driver

PPARGC1A
Ensembl id ENSG00000109819
Mutated samples
Coding Sequence 93 (1.4%)
Protein Affecting 65 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PPARGC1A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 26 18 4.88
Lung adenocarcinoma No 13 10 2.56
Breast carcinoma No 7 7 0.61
Stomach adenocarcinoma No 11 6 3.73
Lung squamous cell carcinoma No 6 5 2.87
Renal clear cell carcinoma No 3 3 0.72
Prostate adenocarcinoma No 3 2 0.82
Bladder carcinoma No 2 2 2.04
Uterine corpus endometrioid carcinoma No 3 2 0.87
Serous ovarian adenocarcinoma No 2 2 0.63
Head and neck squamous cell carcinoma No 2 2 0.53
Hepatocarcinoma No 1 1 1.11
Medulloblastoma No 1 1 0.48
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Small cell lung carcinoma No 1 1 1.45
Chronic lymphocytic leukemia No 6 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Esophageal carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence