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POLR3C has not been detected as a mutational cancer driver

POLR3C
Ensembl id ENSG00000186141
Mutated samples
Coding Sequence 28 (0.4%)
Protein Affecting 17 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all POLR3C gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 4 3 0.26
Cutaneous melanoma No 4 3 0.81
Uterine corpus endometrioid carcinoma No 2 2 0.87
Lung adenocarcinoma No 3 1 0.26
Hepatocarcinoma No 1 1 1.11
Bladder carcinoma No 4 1 1.02
Renal clear cell carcinoma No 2 1 0.24
Non small cell lung carcinoma No 1 1 3.23
Stomach adenocarcinoma No 2 1 0.62
Head and neck squamous cell carcinoma No 1 1 0.27
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 1 1 0.68
Serous ovarian adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence