IntOGen - PML gene cancer mutations

PML is detected as a mutational cancer driver

PML reports

Methods
Mutation distribution

Gene details

PML
Ensembl ID ENSG00000140464 Transcript ID ENST00000268058 Protein ID ENSP00000268058
Cancer types where is driver 1 Cohorts where is driver 1 Mutated samples 2 Mutations 334
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence