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PLXNB1 has not been detected as a mutational cancer driver

PLXNB1
Ensembl id ENSG00000164050
Mutated samples
Coding Sequence 112 (1.6%)
Protein Affecting 75 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PLXNB1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 35 28 7.59
Stomach adenocarcinoma No 7 6 3.73
Renal clear cell carcinoma No 7 5 1.20
Breast carcinoma No 5 4 0.35
Uterine corpus endometrioid carcinoma No 10 4 1.74
Lung adenocarcinoma No 5 3 0.77
Lung squamous cell carcinoma No 5 3 1.72
Thyroid carcinoma No 3 3 0.93
Chronic lymphocytic leukemia No 4 3 1.03
Serous ovarian adenocarcinoma No 3 2 0.63
Colorectal adenocarcinoma No 2 2 0.87
Head and neck squamous cell carcinoma No 8 2 0.53
Esophageal carcinoma No 2 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Bladder carcinoma No 4 1 1.02
Pancreas adenocarcinoma No 2 1 0.47
Neuroblastoma No 1 1 0.48
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Diffuse B cell lymphoma No 1 1 4.35
Glioblastoma multiforme No 3 1 0.26
Acute myeloid leukemia No 1 0 0.00
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence