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PLXNA3 has not been detected as a mutational cancer driver

PLXNA3
Ensembl id ENSG00000130827
Mutated samples
Coding Sequence 116 (1.7%)
Protein Affecting 75 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PLXNA3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 30 14 3.79
Head and neck squamous cell carcinoma No 13 9 2.40
Breast carcinoma No 9 8 0.70
Lung adenocarcinoma No 12 7 1.79
Lung squamous cell carcinoma No 8 5 2.87
Stomach adenocarcinoma No 10 5 3.11
Uterine corpus endometrioid carcinoma No 5 4 1.74
Lower grade glioma No 4 4 2.37
Colorectal adenocarcinoma No 4 4 1.75
Esophageal carcinoma No 4 4 2.74
Renal clear cell carcinoma No 3 3 0.72
Small cell lung carcinoma No 3 3 4.35
Glioblastoma multiforme No 4 2 0.53
Bladder carcinoma No 2 1 1.02
Chronic lymphocytic leukemia No 1 1 0.34
Serous ovarian adenocarcinoma No 1 1 0.32
Acute myeloid leukemia No 1 0 0.00
Neuroblastoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence