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PLXNA2 has not been detected as a mutational cancer driver

PLXNA2
Ensembl id ENSG00000076356
Mutated samples
Coding Sequence 115 (1.7%)
Protein Affecting 76 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PLXNA2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Breast carcinoma No 12 10 0.87
Uterine corpus endometrioid carcinoma No 10 10 4.35
Cutaneous melanoma No 22 9 2.44
Stomach adenocarcinoma No 9 8 4.97
Head and neck squamous cell carcinoma No 12 8 2.13
Lung adenocarcinoma No 10 7 1.79
Lung squamous cell carcinoma No 6 3 1.72
Chronic lymphocytic leukemia No 11 3 1.03
Serous ovarian adenocarcinoma No 3 3 0.95
Glioblastoma multiforme No 3 3 0.79
Hepatocarcinoma No 2 2 2.22
Renal clear cell carcinoma No 2 2 0.48
Esophageal carcinoma No 2 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 2 1 3.23
Small cell lung carcinoma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Diffuse B cell lymphoma No 1 1 4.35
Bladder carcinoma No 1 0 0.00
Medulloblastoma No 2 0 0.00
Neuroblastoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence