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PLXNA1 is detected as a mutational cancer driver in 1 cancer type: Prostate adenocarcinoma

PLXNA1
Ensembl id ENSG00000114554
Mutated samples
Coding Sequence 132 (1.9%)
Protein Affecting 82 (1.2%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
PRAD C
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PLXNA1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Prostate adenocarcinoma Yes 5 3 1.23
Cutaneous melanoma No 33 16 4.34
Head and neck squamous cell carcinoma No 22 15 4.00
Lung squamous cell carcinoma No 9 9 5.17
Uterine corpus endometrioid carcinoma No 10 9 3.91
Lung adenocarcinoma No 10 8 2.05
Breast carcinoma No 9 6 0.52
Lower grade glioma No 4 3 1.78
Stomach adenocarcinoma No 8 3 1.86
Renal clear cell carcinoma No 5 2 0.48
Small cell lung carcinoma No 3 2 2.90
Esophageal carcinoma No 3 2 1.37
Bladder carcinoma No 3 1 1.02
Medulloblastoma No 2 1 0.48
Pancreas adenocarcinoma No 1 1 0.47
Glioblastoma multiforme No 2 1 0.26
Chronic lymphocytic leukemia No 2 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence