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PLK4 has not been detected as a mutational cancer driver

PLK4
Ensembl id ENSG00000142731
Mutated samples
Coding Sequence 44 (0.6%)
Protein Affecting 33 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PLK4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 8 6 1.53
Cutaneous melanoma No 8 5 1.36
Breast carcinoma No 5 4 0.35
Head and neck squamous cell carcinoma No 4 4 1.07
Bladder carcinoma No 3 3 3.06
Uterine corpus endometrioid carcinoma No 2 2 0.87
Colorectal adenocarcinoma No 2 2 0.87
Prostate adenocarcinoma No 2 1 0.41
Lung squamous cell carcinoma No 1 1 0.57
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Multiple myeloma No 1 1 1.45
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 2 1 0.68
Chronic lymphocytic leukemia No 1 0 0.00
Stomach adenocarcinoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence