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PLEKHM2 has not been detected as a mutational cancer driver

PLEKHM2
Ensembl id ENSG00000116786
Mutated samples
Coding Sequence 51 (0.8%)
Protein Affecting 24 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PLEKHM2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 17 7 1.90
Head and neck squamous cell carcinoma No 6 4 1.07
Lung adenocarcinoma No 2 2 0.51
Bladder carcinoma No 2 2 2.04
Breast carcinoma No 3 2 0.17
Serous ovarian adenocarcinoma No 2 2 0.63
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Chronic lymphocytic leukemia No 4 1 0.34
Glioblastoma multiforme No 2 1 0.26
Esophageal carcinoma No 1 1 0.68
Medulloblastoma No 1 0 0.00
Lung squamous cell carcinoma No 3 0 0.00
Uterine corpus endometrioid carcinoma No 4 0 0.00
Stomach adenocarcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence