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PLEKHB2 has not been detected as a mutational cancer driver

PLEKHB2
Ensembl id ENSG00000115762
Mutated samples
Coding Sequence 177 (2.6%)
Protein Affecting 18 (0.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PLEKHB2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 17 3 0.77
Breast carcinoma No 5 3 0.26
Cutaneous melanoma No 82 2 0.54
Serous ovarian adenocarcinoma No 4 2 0.63
Stomach adenocarcinoma No 9 2 1.24
Lung squamous cell carcinoma No 16 1 0.57
Renal clear cell carcinoma No 2 1 0.24
Uterine corpus endometrioid carcinoma No 7 1 0.43
Head and neck squamous cell carcinoma No 8 1 0.27
Esophageal carcinoma No 4 1 0.68
Acute lymphocytic leukemia No 1 1 0.82
Prostate adenocarcinoma No 2 0 0.00
Hepatocarcinoma No 3 0 0.00
Bladder carcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Thyroid carcinoma No 3 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Lower grade glioma No 1 0 0.00
Colorectal adenocarcinoma No 2 0 0.00
Glioblastoma multiforme No 7 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence