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PLEKHA6 has not been detected as a mutational cancer driver

PLEKHA6
Ensembl id ENSG00000143850
Mutated samples
Coding Sequence 94 (1.4%)
Protein Affecting 69 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PLEKHA6 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 21 14 3.79
Breast carcinoma No 8 8 0.70
Head and neck squamous cell carcinoma No 8 8 2.13
Lung adenocarcinoma No 10 7 1.79
Uterine corpus endometrioid carcinoma No 7 6 2.61
Renal clear cell carcinoma No 5 4 0.96
Prostate adenocarcinoma No 3 3 1.23
Lung squamous cell carcinoma No 6 3 1.72
Stomach adenocarcinoma No 4 3 1.86
Hepatocarcinoma No 5 2 2.22
Serous ovarian adenocarcinoma No 2 2 0.63
Colorectal adenocarcinoma No 4 2 0.87
Esophageal carcinoma No 2 2 1.37
Bladder carcinoma No 1 1 1.02
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Small cell lung carcinoma No 1 1 1.45
Glioblastoma multiforme No 1 1 0.26
Medulloblastoma No 1 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence