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PLCL1 has not been detected as a mutational cancer driver

PLCL1
Ensembl id ENSG00000115896
Mutated samples
Coding Sequence 161 (2.4%)
Protein Affecting 114 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PLCL1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 38 27 7.32
Lung adenocarcinoma No 18 16 4.09
Lung squamous cell carcinoma No 15 12 6.90
Stomach adenocarcinoma No 13 10 6.21
Head and neck squamous cell carcinoma No 9 9 2.40
Esophageal carcinoma No 15 9 6.16
Uterine corpus endometrioid carcinoma No 10 7 3.04
Breast carcinoma No 6 5 0.44
Small cell lung carcinoma No 6 5 7.25
Glioblastoma multiforme No 6 4 1.06
Chronic lymphocytic leukemia No 10 3 1.03
Bladder carcinoma No 2 2 2.04
Prostate adenocarcinoma No 1 1 0.41
Hepatocarcinoma No 6 1 1.11
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Colorectal adenocarcinoma No 1 1 0.44
Serous ovarian adenocarcinoma No 1 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence