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PKN2 has not been detected as a mutational cancer driver

PKN2
Ensembl id ENSG00000065243
Mutated samples
Coding Sequence 53 (0.8%)
Protein Affecting 38 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PKN2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 6 6 1.53
Breast carcinoma No 6 6 0.52
Cutaneous melanoma No 6 5 1.36
Lung squamous cell carcinoma No 3 3 1.72
Renal clear cell carcinoma No 4 3 0.72
Stomach adenocarcinoma No 4 3 1.86
Head and neck squamous cell carcinoma No 4 3 0.80
Prostate adenocarcinoma No 2 2 0.82
Small cell lung carcinoma No 2 2 2.90
Bladder carcinoma No 2 1 1.02
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 1 1 3.23
Colorectal adenocarcinoma No 2 1 0.44
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Diffuse B cell lymphoma No 2 0 0.00
Esophageal carcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence