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PIN4 has not been detected as a mutational cancer driver

PIN4
Ensembl id ENSG00000102309
Mutated samples
Coding Sequence 77 (1.1%)
Protein Affecting 3 (0.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PIN4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma No 5 1 0.57
Small cell lung carcinoma No 3 1 1.45
Head and neck squamous cell carcinoma No 3 1 0.27
Lung adenocarcinoma No 7 0 0.00
Hepatocarcinoma No 2 0 0.00
Breast carcinoma No 11 0 0.00
Medulloblastoma No 1 0 0.00
Renal clear cell carcinoma No 1 0 0.00
Cutaneous melanoma No 17 0 0.00
Neuroblastoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 7 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Serous ovarian adenocarcinoma No 3 0 0.00
Stomach adenocarcinoma No 3 0 0.00
Colorectal adenocarcinoma No 3 0 0.00
Glioblastoma multiforme No 5 0 0.00
Esophageal carcinoma No 2 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence