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PIKFYVE has not been detected as a mutational cancer driver

PIKFYVE
Ensembl id ENSG00000115020
Mutated samples
Coding Sequence 138 (2.0%)
Protein Affecting 109 (1.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PIKFYVE gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 33 27 7.32
Uterine corpus endometrioid carcinoma No 13 13 5.65
Lung adenocarcinoma No 18 12 3.07
Lung squamous cell carcinoma No 13 10 5.75
Breast carcinoma No 11 8 0.70
Head and neck squamous cell carcinoma No 10 8 2.13
Serous ovarian adenocarcinoma No 7 7 2.22
Prostate adenocarcinoma No 5 5 2.06
Glioblastoma multiforme No 4 4 1.06
Small cell lung carcinoma No 4 3 4.35
Colorectal adenocarcinoma No 3 3 1.31
Renal clear cell carcinoma No 3 2 0.48
Neuroblastoma No 2 2 0.95
Esophageal carcinoma No 2 2 1.37
Hepatocarcinoma No 2 1 1.11
Bladder carcinoma No 2 1 1.02
Medulloblastoma No 1 1 0.48
Pancreas adenocarcinoma No 2 0 0.00
Stomach adenocarcinoma No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence