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PIK3R4 has not been detected as a mutational cancer driver

PIK3R4
Ensembl id ENSG00000196455
Mutated samples
Coding Sequence 89 (1.3%)
Protein Affecting 68 (1.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PIK3R4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 15 10 2.71
Lung adenocarcinoma No 9 8 2.05
Breast carcinoma No 8 8 0.70
Lung squamous cell carcinoma No 7 6 3.45
Head and neck squamous cell carcinoma No 9 6 1.60
Uterine corpus endometrioid carcinoma No 6 5 2.17
Serous ovarian adenocarcinoma No 5 4 1.27
Stomach adenocarcinoma No 7 4 2.48
Bladder carcinoma No 3 3 3.06
Small cell lung carcinoma No 3 3 4.35
Hepatocarcinoma No 3 2 2.22
Renal clear cell carcinoma No 5 2 0.48
Colorectal adenocarcinoma No 3 2 0.87
Prostate adenocarcinoma No 1 1 0.41
Pancreas adenocarcinoma No 1 1 0.47
Multiple myeloma No 2 1 1.45
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 1 1 0.68
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence