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PHLDB2 has not been detected as a mutational cancer driver

PHLDB2
Ensembl id ENSG00000144824
Mutated samples
Coding Sequence 137 (2.0%)
Protein Affecting 91 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PHLDB2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 50 38 10.30
Lung adenocarcinoma No 8 7 1.79
Breast carcinoma No 10 7 0.61
Bladder carcinoma No 7 5 5.10
Lung squamous cell carcinoma No 11 5 2.87
Stomach adenocarcinoma No 7 5 3.11
Uterine corpus endometrioid carcinoma No 4 4 1.74
Glioblastoma multiforme No 6 4 1.06
Esophageal carcinoma No 5 4 2.74
Colorectal adenocarcinoma No 4 3 1.31
Head and neck squamous cell carcinoma No 8 3 0.80
Serous ovarian adenocarcinoma No 4 2 0.63
Thyroid carcinoma No 2 1 0.31
Chronic lymphocytic leukemia No 5 1 0.34
Lower grade glioma No 1 1 0.59
Small cell lung carcinoma No 1 1 1.45
Prostate adenocarcinoma No 1 0 0.00
Hepatocarcinoma No 2 0 0.00
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence