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PHEX has not been detected as a mutational cancer driver

PHEX
Ensembl id ENSG00000102174
Mutated samples
Coding Sequence 59 (0.9%)
Protein Affecting 43 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PHEX gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 11 8 2.17
Lung squamous cell carcinoma No 7 7 4.02
Lung adenocarcinoma No 6 5 1.28
Breast carcinoma No 5 5 0.44
Colorectal adenocarcinoma No 4 4 1.75
Head and neck squamous cell carcinoma No 4 3 0.80
Serous ovarian adenocarcinoma No 2 2 0.63
Stomach adenocarcinoma No 2 2 1.24
Small cell lung carcinoma No 2 2 2.90
Thyroid carcinoma No 2 1 0.31
Uterine corpus endometrioid carcinoma No 2 1 0.43
Non small cell lung carcinoma No 1 1 3.23
Glioblastoma multiforme No 3 1 0.26
Acute lymphocytic leukemia No 2 1 0.82
Bladder carcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Lower grade glioma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence