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PER3 has not been detected as a mutational cancer driver

PER3
Ensembl id ENSG00000049246
Mutated samples
Coding Sequence 65 (1.0%)
Protein Affecting 48 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PER3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 17 11 2.98
Breast carcinoma No 8 8 0.70
Head and neck squamous cell carcinoma No 10 8 2.13
Stomach adenocarcinoma No 4 3 1.86
Colorectal adenocarcinoma No 3 3 1.31
Prostate adenocarcinoma No 2 2 0.82
Bladder carcinoma No 3 2 2.04
Lung squamous cell carcinoma No 3 2 1.15
Glioblastoma multiforme No 2 2 0.53
Lung adenocarcinoma No 2 1 0.26
Hepatocarcinoma No 2 1 1.11
Medulloblastoma No 1 1 0.48
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 1 1 0.24
Uterine corpus endometrioid carcinoma No 1 1 0.43
Serous ovarian adenocarcinoma No 1 1 0.32
Neuroblastoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence