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PDZRN3 has not been detected as a mutational cancer driver

PDZRN3
Ensembl id ENSG00000121440
Mutated samples
Coding Sequence 122 (1.8%)
Protein Affecting 89 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PDZRN3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 23 16 4.34
Lung adenocarcinoma No 16 14 3.58
Head and neck squamous cell carcinoma No 14 11 2.93
Lung squamous cell carcinoma No 12 9 5.17
Esophageal carcinoma No 10 7 4.79
Bladder carcinoma No 6 5 5.10
Breast carcinoma No 5 4 0.35
Small cell lung carcinoma No 4 4 5.80
Prostate adenocarcinoma No 4 3 1.23
Serous ovarian adenocarcinoma No 4 3 0.95
Stomach adenocarcinoma No 6 3 1.86
Hepatocarcinoma No 4 2 2.22
Colorectal adenocarcinoma No 3 2 0.87
Pancreas adenocarcinoma No 1 1 0.47
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Uterine corpus endometrioid carcinoma No 1 1 0.43
Multiple myeloma No 1 1 1.45
Glioblastoma multiforme No 2 1 0.26
Neuroblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 3 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence