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PDS5A has not been detected as a mutational cancer driver

PDS5A
Ensembl id ENSG00000121892
Mutated samples
Coding Sequence 63 (0.9%)
Protein Affecting 47 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PDS5A gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 16 10 2.71
Lung adenocarcinoma No 7 7 1.79
Breast carcinoma No 8 6 0.52
Lung squamous cell carcinoma No 5 5 2.87
Renal clear cell carcinoma No 4 4 0.96
Stomach adenocarcinoma No 4 4 2.48
Bladder carcinoma No 2 2 2.04
Uterine corpus endometrioid carcinoma No 3 2 0.87
Head and neck squamous cell carcinoma No 4 2 0.53
Glioblastoma multiforme No 2 2 0.53
Thyroid carcinoma No 2 1 0.31
Multiple myeloma No 1 1 1.45
Colorectal adenocarcinoma No 1 1 0.44
Hepatocarcinoma No 1 0 0.00
Neuroblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence