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PCDH19 has not been detected as a mutational cancer driver

PCDH19
Ensembl id ENSG00000165194
Mutated samples
Coding Sequence 147 (2.2%)
Protein Affecting 99 (1.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PCDH19 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 28 19 5.15
Breast carcinoma No 17 16 1.39
Stomach adenocarcinoma No 12 11 6.83
Lung adenocarcinoma No 13 10 2.56
Uterine corpus endometrioid carcinoma No 11 7 3.04
Lung squamous cell carcinoma No 9 5 2.87
Small cell lung carcinoma No 4 4 5.80
Colorectal adenocarcinoma No 6 4 1.75
Glioblastoma multiforme No 7 4 1.06
Medulloblastoma No 3 3 1.43
Head and neck squamous cell carcinoma No 4 3 0.80
Prostate adenocarcinoma No 2 2 0.82
Bladder carcinoma No 4 2 2.04
Lower grade glioma No 5 2 1.18
Esophageal carcinoma No 4 2 1.37
Hepatocarcinoma No 2 1 1.11
Renal clear cell carcinoma No 3 1 0.24
Non small cell lung carcinoma No 1 1 3.23
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 2 1 0.32
Acute myeloid leukemia No 1 0 0.00
Chronic lymphocytic leukemia No 6 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence