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PCDH18 is detected as a mutational cancer driver in 2 cancer types: Bladder carcinoma, Cutaneous melanoma and in the PAN-cancer analysis

PCDH18
Ensembl id ENSG00000189184
Mutated samples
Coding Sequence 186 (2.7%)
Protein Affecting 153 (2.3%)
Mode of action Activating
Known driver No
Cancer type Signals (Biases)
BLCA F
CM F
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PCDH18 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 84 69 18.70
Head and neck squamous cell carcinoma Yes 9 8 2.13
Breast carcinoma Yes 7 7 0.61
Bladder carcinoma Yes 5 5 5.10
Pancreas adenocarcinoma Yes 4 4 1.87
Prostate adenocarcinoma Yes 4 3 1.23
Lung squamous cell carcinoma Yes 3 3 1.72
Uterine corpus endometrioid carcinoma Yes 5 3 1.30
Renal clear cell carcinoma Yes 2 2 0.48
Glioblastoma multiforme Yes 3 2 0.53
Lung adenocarcinoma No 18 16 4.09
Esophageal carcinoma No 14 13 8.90
Stomach adenocarcinoma No 12 7 4.35
Colorectal adenocarcinoma No 5 5 2.18
Hepatocarcinoma No 2 1 1.11
Chronic lymphocytic leukemia No 3 1 0.34
Multiple myeloma No 1 1 1.45
Lower grade glioma No 2 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence