PARS2 has not been detected as a mutational cancer driver

Ensembl id ENSG00000162396
Mutated samples
Coding Sequence 28 (0.4%)
Protein Affecting 16 (0.2%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PARS2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma No 3 3 1.72
Renal clear cell carcinoma No 2 2 0.48
Uterine corpus endometrioid carcinoma No 2 2 0.87
Head and neck squamous cell carcinoma No 2 2 0.53
Breast carcinoma No 2 1 0.09
Cutaneous melanoma No 9 1 0.27
Neuroblastoma No 1 1 0.48
Serous ovarian adenocarcinoma No 2 1 0.32
Stomach adenocarcinoma No 2 1 0.62
Glioblastoma multiforme No 1 1 0.26
Acute lymphocytic leukemia No 1 1 0.82
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence