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PARP15 has not been detected as a mutational cancer driver

PARP15
Ensembl id ENSG00000173200
Mutated samples
Coding Sequence 45 (0.7%)
Protein Affecting 33 (0.5%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PARP15 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 16 14 3.79
Lung adenocarcinoma No 3 3 0.77
Uterine corpus endometrioid carcinoma No 3 3 1.30
Breast carcinoma No 2 2 0.17
Head and neck squamous cell carcinoma No 4 2 0.53
Hepatocarcinoma No 3 1 1.11
Bladder carcinoma No 1 1 1.02
Lung squamous cell carcinoma No 4 1 0.57
Renal clear cell carcinoma No 1 1 0.24
Chronic lymphocytic leukemia No 2 1 0.34
Multiple myeloma No 1 1 1.45
Serous ovarian adenocarcinoma No 1 1 0.32
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 1 1 0.68
Stomach adenocarcinoma No 1 0 0.00
Colorectal adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence