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PAPPA2 has not been detected as a mutational cancer driver

PAPPA2
Ensembl id ENSG00000116183
Mutated samples
Coding Sequence 350 (5.2%)
Protein Affecting 266 (3.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all PAPPA2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 118 87 23.58
Lung adenocarcinoma No 47 36 9.21
Head and neck squamous cell carcinoma No 35 30 8.00
Lung squamous cell carcinoma No 36 29 16.67
Stomach adenocarcinoma No 20 14 8.70
Breast carcinoma No 12 12 1.05
Small cell lung carcinoma No 11 10 14.49
Serous ovarian adenocarcinoma No 7 7 2.22
Esophageal carcinoma No 9 7 4.79
Glioblastoma multiforme No 7 5 1.32
Bladder carcinoma No 4 4 4.08
Uterine corpus endometrioid carcinoma No 7 4 1.74
Non small cell lung carcinoma No 6 4 12.90
Colorectal adenocarcinoma No 5 4 1.75
Renal clear cell carcinoma No 5 3 0.72
Prostate adenocarcinoma No 2 2 0.82
Pancreas adenocarcinoma No 2 2 0.93
Hepatocarcinoma No 3 1 1.11
Acute myeloid leukemia No 1 1 0.51
Neuroblastoma No 2 1 0.48
Chronic lymphocytic leukemia No 9 1 0.34
Lower grade glioma No 1 1 0.59
Acute lymphocytic leukemia No 1 1 0.82
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence