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OTOF has not been detected as a mutational cancer driver

OTOF
Ensembl id ENSG00000115155
Mutated samples
Coding Sequence 193 (2.8%)
Protein Affecting 135 (2.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all OTOF gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 56 37 10.03
Breast carcinoma No 21 17 1.48
Lung adenocarcinoma No 19 12 3.07
Lung squamous cell carcinoma No 12 12 6.90
Uterine corpus endometrioid carcinoma No 14 8 3.48
Stomach adenocarcinoma No 10 8 4.97
Serous ovarian adenocarcinoma No 6 6 1.90
Bladder carcinoma No 7 5 5.10
Renal clear cell carcinoma No 6 5 1.20
Prostate adenocarcinoma No 3 3 1.23
Lower grade glioma No 3 3 1.78
Colorectal adenocarcinoma No 5 3 1.31
Head and neck squamous cell carcinoma No 12 3 0.80
Glioblastoma multiforme No 3 3 0.79
Esophageal carcinoma No 5 3 2.05
Hepatocarcinoma No 3 2 2.22
Non small cell lung carcinoma No 2 2 6.45
Chronic lymphocytic leukemia No 1 1 0.34
Small cell lung carcinoma No 3 1 1.45
Acute lymphocytic leukemia No 1 1 0.82
Pancreas adenocarcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence