IntOGen - NTRK3 gene cancer mutations

NTRK3 is detected as a mutational cancer driver

NTRK3 reports

Methods
Mutation distribution

Gene details

NTRK3
Ensembl ID ENSG00000140538 Transcript ID ENST00000360948 Protein ID ENSP00000354207
Cancer types where is driver 1 Cohorts where is driver 1 Mutated samples 10 Mutations 766
Mode of action Loss of function
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence