IntOGen - NSD2 gene cancer mutations

NSD2 is detected as a mutational cancer driver

NSD2 reports

Methods
Mutation distribution

Gene details

NSD2
Ensembl ID ENSG00000109685 Transcript ID ENST00000382895 Protein ID ENSP00000372351
Cancer types where is driver 3 Cohorts where is driver 3 Mutated samples 17 Mutations 451
Mode of action Ambiguous
Known driver True

Method signals per Cancer Type

Cancer type	Methods	Samples	Samples (%)

ClustL HotMAPS smRegions Clustered Mutations
CBaSE dNdScv Recurrent Mutations
FML Functional Mutations
MutPanning Tri-nucleotide specific bias
combination Combination

The mutations needle plot shows the distribution of the observed mutations along the protein sequence.

Mutation (GRCh38)	Protein Position	Samples	Consequence