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NRAS is detected as a mutational cancer driver in 2 Cutaneous melanoma projects

Cutaneous melanoma
Projects 2
369 Samples
Coding sequence mutations (CSMs)
in driver genes 4035
in all genes 413513
Protein affecting mutations (PAMs)
in driver genes 2994
in all genes 167055
NRAS
Ensembl id ENSG00000213281
Mutated samples
Coding Sequence 103 (27.9%)
Protein Affecting 100 (27.1%)
Mode of action Activating
Known driver Yes
Project Signals
CM_TCGA RFC
CM_BROAD FC
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Cutaneous melanoma projects in all NRAS gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Skin cutaneous melanoma TCGA obtained from Synapse Yes 72 70 18.97
Skin cutaneous melanoma BROAD obtained from Alexandrov Yes 31 30 8.13
The mutations needle plot shows the distribution of the observed NRAS cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification