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NR4A2 mutations in 8 cancer types possibly contribute to the detection of the gene in the PAN-cancer anlaysis:: Breast carcinoma, Lung squamous cell carcinoma, Cutaneous melanoma, Serous ovarian adenocarcinoma, Stomach adenocarcinoma, Small cell lung carcinoma, Colorectal adenocarcinoma, Head and neck squamous cell carcinoma

NR4A2
Ensembl id ENSG00000153234
Mutated samples
Coding Sequence 59 (0.9%)
Protein Affecting 46 (0.7%)
Mode of action Loss of function
Known driver No
Cancer type Signals (Biases)
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NR4A2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma Yes 10 7 1.90
Breast carcinoma Yes 5 5 0.44
Stomach adenocarcinoma Yes 7 5 3.11
Lung squamous cell carcinoma Yes 5 4 2.30
Serous ovarian adenocarcinoma Yes 5 3 0.95
Small cell lung carcinoma Yes 3 3 4.35
Colorectal adenocarcinoma Yes 2 2 0.87
Head and neck squamous cell carcinoma Yes 2 2 0.53
Lung adenocarcinoma No 7 7 1.79
Uterine corpus endometrioid carcinoma No 4 4 1.74
Bladder carcinoma No 1 1 1.02
Renal clear cell carcinoma No 1 1 0.24
Thyroid carcinoma No 1 1 0.31
Neuroblastoma No 1 1 0.48
Hepatocarcinoma No 1 0 0.00
Medulloblastoma No 1 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence