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NR3C2 has not been detected as a mutational cancer driver

NR3C2
Ensembl id ENSG00000151623
Mutated samples
Coding Sequence 96 (1.4%)
Protein Affecting 62 (0.9%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NR3C2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 23 19 5.15
Stomach adenocarcinoma No 8 6 3.73
Lung adenocarcinoma No 5 5 1.28
Colorectal adenocarcinoma No 6 5 2.18
Head and neck squamous cell carcinoma No 8 5 1.33
Glioblastoma multiforme No 4 4 1.06
Breast carcinoma No 4 3 0.26
Lung squamous cell carcinoma No 5 3 1.72
Bladder carcinoma No 3 2 2.04
Neuroblastoma No 2 2 0.95
Hepatocarcinoma No 2 1 1.11
Medulloblastoma No 4 1 0.48
Thyroid carcinoma No 1 1 0.31
Uterine corpus endometrioid carcinoma No 2 1 0.43
Chronic lymphocytic leukemia No 13 1 0.34
Multiple myeloma No 1 1 1.45
Small cell lung carcinoma No 1 1 1.45
Esophageal carcinoma No 2 1 0.68
Renal clear cell carcinoma No 1 0 0.00
Lower grade glioma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence