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NPR1 has not been detected as a mutational cancer driver

NPR1
Ensembl id ENSG00000169418
Mutated samples
Coding Sequence 73 (1.1%)
Protein Affecting 49 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NPR1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 23 16 4.34
Lung adenocarcinoma No 7 5 1.28
Breast carcinoma No 5 4 0.35
Stomach adenocarcinoma No 4 4 2.48
Lung squamous cell carcinoma No 5 3 1.72
Renal clear cell carcinoma No 4 3 0.72
Small cell lung carcinoma No 2 2 2.90
Colorectal adenocarcinoma No 3 2 0.87
Head and neck squamous cell carcinoma No 4 2 0.53
Glioblastoma multiforme No 2 2 0.53
Esophageal carcinoma No 3 2 1.37
Pancreas adenocarcinoma No 1 1 0.47
Thyroid carcinoma No 1 1 0.31
Lower grade glioma No 3 1 0.59
Serous ovarian adenocarcinoma No 2 1 0.32
Hepatocarcinoma No 1 0 0.00
Uterine corpus endometrioid carcinoma No 1 0 0.00
Non small cell lung carcinoma No 1 0 0.00
Multiple myeloma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence