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NPHP3 has not been detected as a mutational cancer driver

NPHP3
Ensembl id ENSG00000113971
Mutated samples
Coding Sequence 148 (2.2%)
Protein Affecting 48 (0.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NPHP3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma No 13 10 2.67
Cutaneous melanoma No 24 7 1.90
Renal clear cell carcinoma No 9 5 1.20
Breast carcinoma No 14 4 0.35
Uterine corpus endometrioid carcinoma No 12 4 1.74
Lung adenocarcinoma No 10 2 0.51
Bladder carcinoma No 6 2 2.04
Lung squamous cell carcinoma No 12 2 1.15
Serous ovarian adenocarcinoma No 5 2 0.63
Stomach adenocarcinoma No 9 2 1.24
Small cell lung carcinoma No 2 2 2.90
Glioblastoma multiforme No 6 2 0.53
Hepatocarcinoma No 6 1 1.11
Chronic lymphocytic leukemia No 1 1 0.34
Colorectal adenocarcinoma No 8 1 0.44
Esophageal carcinoma No 2 1 0.68
Prostate adenocarcinoma No 1 0 0.00
Medulloblastoma No 2 0 0.00
Thyroid carcinoma No 2 0 0.00
Multiple myeloma No 1 0 0.00
Lower grade glioma No 1 0 0.00
Diffuse B cell lymphoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence