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NPHP1 has not been detected as a mutational cancer driver

NPHP1
Ensembl id ENSG00000144061
Mutated samples
Coding Sequence 55 (0.8%)
Protein Affecting 41 (0.6%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NPHP1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 21 13 3.52
Lung adenocarcinoma No 5 4 1.02
Renal clear cell carcinoma No 4 4 0.96
Breast carcinoma No 3 3 0.26
Neuroblastoma No 3 3 1.43
Hepatocarcinoma No 2 2 2.22
Multiple myeloma No 2 2 2.90
Serous ovarian adenocarcinoma No 2 2 0.63
Lung squamous cell carcinoma No 2 1 0.57
Uterine corpus endometrioid carcinoma No 1 1 0.43
Chronic lymphocytic leukemia No 2 1 0.34
Stomach adenocarcinoma No 1 1 0.62
Colorectal adenocarcinoma No 2 1 0.44
Head and neck squamous cell carcinoma No 1 1 0.27
Glioblastoma multiforme No 1 1 0.26
Esophageal carcinoma No 2 1 0.68
Diffuse B cell lymphoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence