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NOTCH2 is detected as a mutational cancer driver in 1 Head and neck squamous cell carcinoma project

Head and neck squamous cell carcinoma
Projects 2
375 Samples
Coding sequence mutations (CSMs)
in driver genes 1727
in all genes 90856
Protein affecting mutations (PAMs)
in driver genes 1519
in all genes 46037
NOTCH2
Ensembl id ENSG00000134250
Mutated samples
Coding Sequence 20 (5.3%)
Protein Affecting 17 (4.5%)
Mode of action Unclassified
Known driver Yes
Project Signals
HNSC_TCGA F
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Head and neck squamous cell carcinoma projects in all NOTCH2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Head and neck squamous cell carcinoma TCGA Yes 15 13 3.47
Head and neck squamous cell carcinoma BROAD No 5 4 1.07
The mutations needle plot shows the distribution of the observed NOTCH2 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification