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NLRP3 has not been detected as a mutational cancer driver

NLRP3
Ensembl id ENSG00000162711
Mutated samples
Coding Sequence 270 (4.0%)
Protein Affecting 137 (2.0%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NLRP3 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 89 37 10.03
Lung adenocarcinoma No 51 33 8.44
Lung squamous cell carcinoma No 25 10 5.75
Breast carcinoma No 12 7 0.61
Small cell lung carcinoma No 12 7 10.14
Head and neck squamous cell carcinoma No 15 7 1.87
Glioblastoma multiforme No 7 6 1.58
Serous ovarian adenocarcinoma No 7 5 1.58
Uterine corpus endometrioid carcinoma No 10 4 1.74
Prostate adenocarcinoma No 5 3 1.23
Bladder carcinoma No 5 3 3.06
Neuroblastoma No 4 3 1.43
Pancreas adenocarcinoma No 3 2 0.93
Renal clear cell carcinoma No 3 2 0.48
Stomach adenocarcinoma No 5 2 1.24
Colorectal adenocarcinoma No 7 2 0.87
Thyroid carcinoma No 1 1 0.31
Non small cell lung carcinoma No 2 1 3.23
Chronic lymphocytic leukemia No 2 1 0.34
Multiple myeloma No 1 1 1.45
Lower grade glioma No 2 0 0.00
Esophageal carcinoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence