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NLRP12 has not been detected as a mutational cancer driver

NLRP12
Ensembl id ENSG00000142405
Mutated samples
Coding Sequence 153 (2.3%)
Protein Affecting 114 (1.7%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NLRP12 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 46 34 9.21
Head and neck squamous cell carcinoma No 19 15 4.00
Lung adenocarcinoma No 16 13 3.32
Breast carcinoma No 11 9 0.78
Lung squamous cell carcinoma No 9 9 5.17
Glioblastoma multiforme No 9 7 1.85
Stomach adenocarcinoma No 10 6 3.73
Serous ovarian adenocarcinoma No 5 4 1.27
Colorectal adenocarcinoma No 4 3 1.31
Pancreas adenocarcinoma No 2 2 0.93
Uterine corpus endometrioid carcinoma No 3 2 0.87
Small cell lung carcinoma No 2 2 2.90
Esophageal carcinoma No 2 2 1.37
Prostate adenocarcinoma No 1 1 0.41
Renal clear cell carcinoma No 3 1 0.24
Neuroblastoma No 1 1 0.48
Non small cell lung carcinoma No 2 1 3.23
Lower grade glioma No 3 1 0.59
Acute lymphocytic leukemia No 1 1 0.82
Hepatocarcinoma No 1 0 0.00
Bladder carcinoma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence