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NLRC4 has not been detected as a mutational cancer driver

NLRC4
Ensembl id ENSG00000091106
Mutated samples
Coding Sequence 99 (1.5%)
Protein Affecting 72 (1.1%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NLRC4 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 26 19 5.15
Breast carcinoma No 10 8 0.70
Stomach adenocarcinoma No 7 7 4.35
Lung adenocarcinoma No 8 6 1.53
Lung squamous cell carcinoma No 9 6 3.45
Head and neck squamous cell carcinoma No 6 4 1.07
Esophageal carcinoma No 5 4 2.74
Serous ovarian adenocarcinoma No 3 3 0.95
Bladder carcinoma No 3 2 2.04
Neuroblastoma No 2 2 0.95
Chronic lymphocytic leukemia No 2 2 0.69
Small cell lung carcinoma No 2 2 2.90
Prostate adenocarcinoma No 1 1 0.41
Acute myeloid leukemia No 3 1 0.51
Renal clear cell carcinoma No 1 1 0.24
Uterine corpus endometrioid carcinoma No 3 1 0.43
Non small cell lung carcinoma No 1 1 3.23
Lower grade glioma No 1 1 0.59
Glioblastoma multiforme No 1 1 0.26
Hepatocarcinoma No 2 0 0.00
Pancreas adenocarcinoma No 1 0 0.00
Thyroid carcinoma No 1 0 0.00
Acute lymphocytic leukemia No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence