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NLGN1 has not been detected as a mutational cancer driver

NLGN1
Ensembl id ENSG00000169760
Mutated samples
Coding Sequence 136 (2.0%)
Protein Affecting 88 (1.3%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NLGN1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung adenocarcinoma No 18 16 4.09
Lung squamous cell carcinoma No 15 12 6.90
Cutaneous melanoma No 17 12 3.25
Stomach adenocarcinoma No 8 8 4.97
Head and neck squamous cell carcinoma No 12 8 2.13
Breast carcinoma No 5 4 0.35
Small cell lung carcinoma No 5 4 5.80
Esophageal carcinoma No 4 4 2.74
Bladder carcinoma No 4 3 3.06
Colorectal adenocarcinoma No 5 3 1.31
Glioblastoma multiforme No 3 3 0.79
Hepatocarcinoma No 7 2 2.22
Neuroblastoma No 2 2 0.95
Prostate adenocarcinoma No 1 1 0.41
Pancreas adenocarcinoma No 1 1 0.47
Uterine corpus endometrioid carcinoma No 2 1 0.43
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 17 1 0.34
Lower grade glioma No 1 1 0.59
Serous ovarian adenocarcinoma No 1 1 0.32
Renal clear cell carcinoma No 2 0 0.00
Multiple myeloma No 2 0 0.00
Pylocytic astrocytoma No 1 0 0.00
Diffuse B cell lymphoma No 2 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence