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NGLY1 has not been detected as a mutational cancer driver

NGLY1
Ensembl id ENSG00000151092
Mutated samples
Coding Sequence 64 (0.9%)
Protein Affecting 25 (0.4%)
Mode of action Unclassified
Known driver No
Cancer type Signals (Biases)
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NGLY1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Cutaneous melanoma No 15 7 1.90
Bladder carcinoma No 6 5 5.10
Prostate adenocarcinoma No 4 3 1.23
Lung squamous cell carcinoma No 4 3 1.72
Lung adenocarcinoma No 8 2 0.51
Breast carcinoma No 6 1 0.09
Uterine corpus endometrioid carcinoma No 3 1 0.43
Non small cell lung carcinoma No 1 1 3.23
Stomach adenocarcinoma No 3 1 0.62
Head and neck squamous cell carcinoma No 4 1 0.27
Hepatocarcinoma No 2 0 0.00
Renal clear cell carcinoma No 3 0 0.00
Chronic lymphocytic leukemia No 2 0 0.00
Serous ovarian adenocarcinoma No 1 0 0.00
Glioblastoma multiforme No 1 0 0.00
Esophageal carcinoma No 1 0 0.00
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence