NFE2L2 is detected as a mutational cancer driver in Lung Squamous Cell Carcinoma
NFE2L2 reports in Lung Squamous Cell Carcinoma (LUSC)
Cancer type details
Lung Squamous Cell Carcinoma |
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Cohorts
6
Samples 703 Mutations 4,282,647 Driver genes 75 |
Gene details
NFE2L2 |
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Ensembl ID
ENSG00000116044
Transcript ID ENST00000397062 Protein ID ENSP00000380252 |
Cohorts where is driver
4
Mutated samples 98 Mutated samples (%) 13.94 Mutations 109 |
Mode of action Activating |
Known driver True |
Method signals per Cohort
Cohort | Methods | Samples | Samples (%) |
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In-silico saturation mutagenesis
Model | Mutations | Driver mutations | Driver mutations (%) |
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LUSC (Lung Squamous Cell Carcinoma) | 5436 | 104 | 1.91 |
Observed mutations in tumors
Mutation (GRCh38) | Protein Position | Samples | Samples (%) | Consequence | Driver | Driver score |
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