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NFE2L2 is detected as a mutational cancer driver in 5 cancer types: Bladder carcinoma, Lung squamous cell carcinoma, Renal clear cell carcinoma, Uterine corpus endometrioid carcinoma, Head and neck squamous cell carcinoma and in the PAN-cancer analysis

NFE2L2
Ensembl id ENSG00000116044
Mutated samples
Coding Sequence 107 (1.6%)
Protein Affecting 93 (1.4%)
Mode of action Activating
Known driver Yes
Cancer type Signals (Biases)
BLCA F
LUSC FR
RCCC F
UCEC FR
HNSC CFR
PAN
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated cancer types in all NFE2L2 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Cancer type Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Lung squamous cell carcinoma Yes 26 26 14.94
Head and neck squamous cell carcinoma Yes 20 20 5.33
Uterine corpus endometrioid carcinoma Yes 12 12 5.22
Bladder carcinoma Yes 9 9 9.18
Hepatocarcinoma Yes 12 5 5.56
Renal clear cell carcinoma Yes 5 5 1.20
Lung adenocarcinoma Yes 6 4 1.02
Cutaneous melanoma Yes 6 4 1.08
Stomach adenocarcinoma Yes 2 2 1.24
Esophageal carcinoma Yes 2 2 1.37
Breast carcinoma No 2 2 0.17
Non small cell lung carcinoma No 1 1 3.23
Chronic lymphocytic leukemia No 4 1 0.34
The mutations needle plot shows the distribution of the observed cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence