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NF1 is detected as a mutational cancer driver in 2 Glioblastoma multiforme projects

Glioblastoma multiforme
Projects 2
379 Samples
Coding sequence mutations (CSMs)
in driver genes 842
in all genes 34259
Protein affecting mutations (PAMs)
in driver genes 766
in all genes 17598
NF1
Ensembl id ENSG00000196712
Mutated samples
Coding Sequence 51 (13.5%)
Protein Affecting 47 (12.4%)
Mode of action Loss of function
Known driver Yes
Project Signals
GBM_JHU F
GBM_TCGA RF
Clust Clustered Mutations FM Functional Mutations Rec Recurrent Mutations
This plot shows the most recurrently mutated Glioblastoma multiforme projects in all NF1 gene mutations. Each bar of the histogram indicates the amount of samples with PAMs.

Project Driver Mutated samples (CS) Mutated samples (PAM) % Mutated samples (PAM)
Glioblastoma multiforme TCGA Yes 34 31 8.18
Glioblastoma multiforme Johns Hopkins University Yes 17 16 4.22
The mutations needle plot shows the distribution of the observed NF1 cancer mutations along the protein sequence and it's possible mutational clusters and hotspots. The needles' height and head size represent mutational recurrence. Needles of different categories that fall in the same amino acid residues are stacked.

Variant Locus Samples AA pos AA change Consequence Driver classification